Our Services

Sample Processing and Cryopreservation

• Processing of venous blood for isolation and cryopreservation of peripheral blood mononuclear cells (PBMCs)
• Bone marrow aspirate processing and storage
• TIL (Tumor Infiltrating Lymphocytes) processing, expansion and storage
• Serum and Plasma processing and storage
• Perform sample processing verification for all sites prior to study start
• Contact HITS about their optimized processing techniques using different vacutainer tube types, which allow for a longer time prior to processing start

Epitope Discovery

• Enzyme-Linked ImmunoSpot (ELISPOT) assay utilized in the identification of T cell epitopes

Multiparametric Flow Cytometry

• Phenotypic characterization of cells or their activation, proliferation or antigen experience profile
• Functional characterization of cells by Intracellular Cytokine Staining (ICS), CarboxyFluorescein Succinimidyl Ester (CFSE) staining or other proliferative assays, Killing assays, PhosphoFlow, Basophil activation test (BAT), Cell cycling, etc.

Serological Assays

• Identification and quantification proteins and cytokines using MAGPIX Luminex assays

Study Design

• Work with clients to cater documentation to assay needs, as well as regulatory requirements of pre-clinical and Phase I – III clinical studies
• HITS can perform onsite training at study clinical sites to ensure consistent blood processing techniques across the entire study

Next Generation Sequencing

• Certified SomaLogic service provider capable of targeted and custom sequencing of both DNA and RNA samples including T-Cell Receptor (TCR) and B-Cell Receptor (BCR) sequencing

Histology

• Processing, embedding, sectioning and staining of formaldehyde-fixed and cryopreserved tissues using standard histological stains, immunohistochemical stains or custom developed stains